NooLVL™

COMMON NAME

Inositol-enhanced Bonded Arginine Silicate

TOP BENEFITS OF nooLVL^TM

Enhances processing speed and accuracy*

Supports executive function*

Boosts energy*

Promotes muscle performance*

WHAT IS nooLVL^TM?

nooLVL^TM is comprised of two components: Bonded (inositol-stabilized) arginine silicate (Nitrosigine®) plus additional inositol. L-arginine has relatively low bioavailability (~20%) following an oral dose, so high doses are needed to significantly boost blood arginine levels [1]. Nitrosigine® and nooLVL^TM have overcome this limitation by bonding the L-arginine to a silicate–inositol complex, which significantly enhances the bioavailability of L-arginine [2–5]. L-arginine is involved in promoting healthy circulation because it can be used for nitric oxide production. Blood flow to metabolically active tissues, like the brain and muscles, plays a big role in allowing these tissues to perform their functions at a high level. Bonded arginine silicate supports exercise performance and post-exercise recovery by promoting muscle blood flow [6]. It also supports brain performance, enhancing mental accuracy, focus, processing speed, and executive function [5,7,8].

Qualia nooLVL^TM SOURCING

nooLVL^TM has been clinically studied in humans: It has boosted cognitive performance and energy in eSports athletes.

nooLVL^TM is an upgraded version of Nitrosigine^®, an ingredient that supports blood arginine levels and nitric oxide production, enhanced energy, promoted focus and mental acuity, and supported better muscle response following exercise. 

nooLVL^TM is a patented nutritional ingredient from Nutrition 21: It contains Nitrosigine^® (l-arginine bonded to silica and inositol with affirmed GRAS) plus added inositol. 

nooLVL^TM is gluten-free, vegan, and non-GMO.

nooLVL^TM is a trademark of Nutrition 21, LLC.

nooLVL^TM DOSING PRINCIPLES AND RATIONALE

Studied dose of nooLVL^TM has been 1600 mg/day: Nitrosigine® has been 1500 mg/day. Since these are the highest doses that have been given in human research, we consider them to be the upper limit we’d be comfortable with for daily dosing. Since it’s possible that the product this is included in might be used more than once a day (i.e., a person could opt to take two servings), we included a half dose per serving (i.e., 800 mg of nooLVL^TM). In Qualia subjective and objective internal N of 1 testing, the half dose of nooLVL^TM had additive effects when combined with other nootropic ingredients.*

nooLVL^TM KEY MECHANISMS

Supports healthy vascular function*

L-arginine is the substrate for vascular nitric oxide (NO) production by NO synthase (NOS) [9]

Upregulates endothelial NOS (eNOS) [silicate] [10]

Upregulates the blood levels of arginine, silicon, and NO [4]

Supports healthy vascular function [2]

Supports healthy blood pressure [arginine] [11] [inositol] [12,13]

Supports brain function*

Upregulates dopamine release [14–16].

Regulates dopamine transporter (DAT) activity [17–20]. 

Supports neurotransmitter signaling [inositol] [21]

Supports cognitive function*

Supports performance in complex cognitive tests requiring mental flexibility, processing speed and executive functioning [7]

Promotes exercise performance*

Supports exercise performance [arginine] [22]

Supports resistance to exhaustion [arginine] [22]

Supports resistance to muscle fatigue [arginine] [23]

Supports muscle blood flow after exercise [6]

Supports muscle recovery [6]

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, cure, or prevent any disease.

REFERENCES

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[21]S.K. Fisher, J.E. Novak, B.W. Agranoff, J. Neurochem. 82 (2002) 736–754.

[22]H.U. Yavuz, H. Turnagol, A.H. Demirel, Biol. Sport 31 (2014) 187–191.

[23]A. Schaefer, F. Piquard, B. Geny, S. Doutreleau, E. Lampert, B. Mettauer, J. Lonsdorfer, Int. J. Sports Med. 23 (2002) 403–407.