Red Orange Complex™ (Citrus sinensis Fruit Extract)

COMMON NAME

Red orange | Blood orange

TOP BENEFITS OF RED ORANGE COMPLEX^TM 

Supports skin health *

Supports antioxidant defenses *

Supports skin’s ability to adapt to environmental stress *

WHAT IS RED ORANGE COMPLEX^TM?

Red Orange Complex^TM is a standardized fruit extract made from the juice of three pigmented varieties of Sicilian blood orange (Moro, Tarocco, and Sanguinello) grown exclusively in a particular area surrounding Europe’s most active volcano, Mt. Etna in Sicily. Many of the bioactive compounds of Red Orange Complex^TM are antioxidants. Antioxidants are important for all of our tissues. As a single example, they play an important role in supporting skin health. For example, a red-purple pigment found in red oranges called cyanidin-3-glucoside (or chrysanthemin) is a major anthocyanin with a number of biological activities that support skin physiology. Hesperidin is a citrus flavanone that supports the skin in adapting to environmental stress. Ascorbic acid (vitamin C) is found in high concentrations in healthy skin, where it is essential for the production of collagen and supports the free radical-scavenging capacity of the skin.* Red Orange Complex^TM is standardized to contain all of these compounds and more.

Qualia RED ORANGE COMPLEX^TM SOURCING

Red Orange Complex^TM is a standardized extract that contains  2.8-3.2% anthocyanins (cyanidin-3-glucoside), 1.8-2.2% hydroxycinnamic acids (caffeic, cumaric, ferulic, sinapic acids), 8.5-9.5 % flavanones (hesperidin, narirutin), and 5.5-6.5% ascorbic acid. 

Red Orange Complex^TM is made from the juice of Moro, Tarocco, and Sanguinello Sicilian blood oranges. It is produced by Bionap, a company that produces standardized botanical extracts obtained from plants and fruits growing in the areas surrounding Mt Etna UNESCO World Heritage in Sicily.

Red Orange Complex^TM is non-GMO, vegan, and Halal certified.

Red Orange Complex^TM is a trademark of Bionap USA, Inc.

RED ORANGE COMPLEX^TM DOSING PRINCIPLES AND RATIONALE

Red Orange Complex^TM has been used in 6 human clinical studies (the company that makes this citrus fruit extract is committed to scientifically studying it and is continuing to fund additional research). In four of these studies, the dose used was 100 mg daily (2 of the studies used a lower dose of 80 mg). We selected the amount of Red Orange Complex^TM to use in our formula to be consistent with the most common dose used in human studies, and with the dose recommended by the company that produces this extract (see Neurohacker Dosing Principles).* 

RED ORANGE COMPLEX^TM KEY MECHANISMS

Supports skin health*

Supports resilience to environmental stress [1–18]

Supports skin hydration [1]

Supports healthy transepidermal water loss (TEWL) [1]

Supports skin radiance [1]

Supports skin elasticity [1]

Helps minimize the appearance of "crow's feet" [1]

Supports healthy skin pigmentation [2,19]

Influences MMP expression [15]

Supports skin circulation [18,20]

Supports skin antioxidant defenses [1,10,17,21,22] 

Counters ROS production and oxidative stress [3,5–8,10–14,17,21,22]

Supports Nrf2 signaling [23]

Supports healthy immune/cytokine signaling [13,15,20,24]

Supports DNA stability [7,9,10,12,16]

Supports healthy autophagy [6]

Supports ERβ signaling [25]

Supports mitochondrial function [7,12]

Supports antioxidant defenses*

Counters systemic oxidative stress [26–28]  

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.

REFERENCES

[1]V. Nobile, A. Burioli, S. Yu, S. Zhifeng, E. Cestone, V. Insolia, V. Zaccaria, G.A. Malfa, Nutrients 14 (2022).

[2]C. Puglia, A. Offerta, A. Saija, D. Trombetta, C. Venera, Journal of Cosmetic Dermatology 13 (2014) 151–157.

[3]A. Saija, A. Tomaino, R. Lo Cascio, P. Rapisarda, J.C. Dederen, Int. J. Cosmet. Sci. 20 (1998) 331–342.

[4]F. Cimino, M. Cristani, A. Saija, F.P. Bonina, F. Virgili, Biofactors 30 (2007) 129–138.

[5]Y. He, Y. Hu, X. Jiang, T. Chen, Y. Ma, S. Wu, J. Sun, R. Jiao, X. Li, L. Deng, W. Bai, J. Photochem. Photobiol. B 177 (2017) 24–31.

[6]S. Wu, Y. Hu, W. Bai, J. Zhao, C. Huang, C. Wen, L. Deng, D. Lu, Photodermatol. Photoimmunol. Photomed. 35 (2019) 360–368.

[7]Y. Hu, Y. Ma, S. Wu, T. Chen, Y. He, J. Sun, R. Jiao, X. Jiang, Y. Huang, L. Deng, W. Bai, Front. Pharmacol. 7 (2016) 301.

[8]S. Wu, Y. Hu, Z. Li, W. Bai, J. Zhao, C. Huang, Q. Li, C. Fan, L. Deng, D. Lu, Photodermatol. Photoimmunol. Photomed. 34 (2018) 224–231.

[9]F. Cimino, R. Ambra, R. Canali, A. Saija, F. Virgili, J. Agric. Food Chem. 54 (2006) 4041–4047.

[10]P. Pratheeshkumar, Y.-O. Son, X. Wang, S.P. Divya, B. Joseph, J.A. Hitron, L. Wang, D. Kim, Y. Yin, R.V. Roy, J. Lu, Z. Zhang, Y. Wang, X. Shi, Toxicol. Appl. Pharmacol. 280 (2014) 127–137.

[11]M. Ding, R. Feng, S.Y. Wang, L. Bowman, Y. Lu, Y. Qian, V. Castranova, B.-H. Jiang, X. Shi, J. Biol. Chem. 281 (2006) 17359–17368.

[12]S.R.K. Madduma Hewage, M.J. Piao, K.A. Kang, Y.S. Ryu, X. Han, M.C. Oh, U. Jung, I.G. Kim, J.W. Hyun, Biomol. Ther. 24 (2016) 312–319.

[13]M. Li, X.-F. Lin, J. Lu, B.-R. Zhou, D. Luo, J. Photochem. Photobiol. B 165 (2016) 240–245.

[14]A. Petrova, L.M. Davids, F. Rautenbach, J.L. Marnewick, J. Photochem. Photobiol. B 103 (2011) 126–139.

[15]H.J. Lee, A.-R. Im, S.-M. Kim, H.-S. Kang, J.D. Lee, S. Chae, BMC Complement. Altern. Med. 18 (2018) 39.

[16]S. Jin, B. Zhou, D. Luo, Ir. J. Med. Sci. 180 (2011) 709–714.

[17]G. Chandra Jagetia, Transcriptomics 03 (2015).

[18]G. Haddadi, A. Abbaszadeh, M.A. Mosleh-Shirazi, M.A. Okhovat, A. Salajeghe, Z. Ghorbani, J. Cancer Res. Ther. 14 (2018) S1098–S1104.

[19]H.J. Lee, W.J. Lee, S.E. Chang, G.-Y. Lee, Int. J. Mol. Sci. 16 (2015) 18384–18395.

[20]L. Wang, T. He, A. Fu, Z. Mao, L. Yi, S. Tang, J. Yang, Eur. J. Inflam. 16 (2018) 2058739218775255.

[21]W. Li, A.D. Kandhare, A.A. Mukherjee, S.L. Bodhankar, EXCLI J. 17 (2018) 399–419.

[22]M. Vabeiryureilai, K. Lalrinzuali, G.C. Jagetia, Heliyon 5 (2019) e02521.

[23]H. Parhiz, A. Roohbakhsh, F. Soltani, R. Rezaee, M. Iranshahi, Phytother. Res. 29 (2015) 323–331.

[24]V. Cardile, G. Frasca, L. Rizza, P. Rapisarda, F. Bonina, Phytother. Res. 24 (2010) 414–418.

[25]M. Liu, Y. Du, H. Li, L. Wang, D. Ponikwicka-Tyszko, W. Lebiedzinska, A. Pilaszewicz-Puza, H. Liu, L. Zhou, H. Fan, M. Wang, H. You, S. Wolczynnski, N. Rahman, Y.-D. Guo, X. Li, Front. Oncol. 9 (2019) 1110.

[26]F.P. Bonina, C. Leotta, G. Scalia, C. Puglia, D. Trombetta, G. Tringali, A.M. Roccazzello, P. Rapisarda, A. Saija, Diabetes Nutr. Metab. 15 (2002) 14–19.

[27]F.P. Bonina, C. Puglia, F. Cimino, D. Trombetta, G. Tringali, A.M. Roccazzello, E. Insirello, P. Rapisarda, A. Saija, Nutr. Res. 25 (2005) 917–924.

[28]F.P. Bonina, C. Puglia, G. Frasca, F. Cimino, D. Trombetta, G. Tringali, A. Roccazzello, E. Insiriello, P. Rapisarda, A. Saija, Nat. Prod. Res. 22 (2008) 1544–1551.