Sirtmax® Kaempferia parviflora

Common Name

Black Ginger | Black Turmeric | Krachai Dam

Top Benefits of Sirtmax^® 

Supports mitochondrial biogenesis, structure and function*

Supports muscle strength and endurance*

Supports metabolism & healthy blood sugar levels*

Supports healthy weight*

Supports antioxidant defenses*

Supports healthy aging*

Support cardiovascular function*

Supports brain function*

Supports reproductive health*

What is Sirtmax^®?

Kaempferia parviflora is found in the upper Northeastern regions of Thailand. Root extracts have a long history of use and a reputation for being a health tonic and energy enhancer (i.e., Thai ginseng). The novel active constituents are a special type of polyphenol called polymethoxyflavonoids. Sirtmax^® Kaempferia parviflora root extract is standardized for polymethoxyflavonoid content.*

Qualia Sirtmax^® Sourcing

Sirtmax^® has been used in animal and human research studies.

Created by Tokiwa Phytochemicals, a leader in standardized Kaempferia parviflora supplementation. 

Highest concentration, full-spectrum root extract, with double standardization for 5,7-dimethoxyflavone (≥ 4%) along with five Kaempferia parviflora polymethoxyflavonoids (≥ 15%).

Grown in Thailand & Laos.

Sirtmax^® is a registered trademark of Tokiwa Phytochemical Co., Ltd.

Sirtmax^® Dosing Principles and Rationale

We consider Kaempferia parviflora to be in the adaptogenic herb category; following hormetic dosing principles (see Neurohacker Dosing Principles) with a high likelihood of having a hormetic range (i.e., a dosing range below and above which results could be poorer). We have selected to dose this at an amount that is within the studied range in humans.*

Kaempferia parviflora Key Mechanisms

Supports mitochondrial biogenesis*

Supports mitochondrial number [1]

Supports Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1alpha (PGC-1α) [1–3]

Supports transcription factors for mitochondrial biogenesis (estrogen-related receptor-α [ERRα], nuclear respiratory factor-1 [NRF1], and mitochondrial transcription factor A [TFAM]) through activation of PGC-1α [2]

Supports mitochondrial function*

Supports AMP-Activated Protein Kinase (AMPK) [2,3]

Promotes ATP production (output of mitochondrial oxidative phosphorylation) [3]

Promotes mitochondrial β-oxidation (fatty acid metabolism) – upregulates peroxisome proliferator-activated receptor gamma (PPARγ) and delta (PPARδ)  [2,4]

Promotes exercise performance*

Supports endurance performance [1,2,5,6]

Supports post-exercise recovery [1]

Supports muscle strength [5,6]

Supports muscle metabolism (upregulates glycogen synthase and increases glycogen content) [1]

Supports healthy metabolic function*

Supports healthy insulin sensitivity [7]

Promotes cell metabolism (muscle cell precursors [myoblasts] in vitro): promotes glucose uptake and the downregulation of lactic acid production; promotes the expression of glucose transporter 4 (GLUT4) and monocarboxylate transporter 1 (MCT1) [3]

Supports healthy body weight*

Supports healthy fat accumulation and blood/liver lipid levels [4,7,8]

Promotes differentiation of brown adipocyte cells  [4]

Supports uncoupling protein 1 (UCP1) in brown adipose tissue - supports thermogenesis of brown adipose tissue  [4,7,8]

Promotes whole-body energy expenditure through activation of brown adipose tissue [7,9]

Promotes lean body mass [2]

Supports antioxidant defenses*

Supports antioxidant enzymes [5]

Promotes healthy aging and longevity* 

Supports SIRT-1 [2,10]

Counters the production of advanced glycation end-products (AGEs) [10]

Supports healthy cardiovascular function*

Promotes healthy nitric oxide (NO) signaling pathway function [11–14]

Supports endothelial NO synthase (eNOS) [11]

Inhibits phosphodiesterase 5 (PDE-5), the enzyme that cleaves the NO mediator cyclic guanosine monophosphate (cGMP) to 5’GMP [15]

Supports NO signaling pathway in cardiac tissue via upregulated cGMP levels [12]

Promotes vasodilation via the NO signaling pathway [13,14]

Supports brain function*

Influences acetylcholinesterase (AChE)activity [16]

Supports neuroprotective functions [17]

Supports reproductive function*

Supports relaxation of the corpus cavernosum [18]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.

REFERENCES

[1]K. Toda, S. Hitoe, S. Takeda, H. Shimoda, Heliyon 2 (2016) e00115.

[2]M.-B. Kim, T. Kim, C. Kim, J.-K. Hwang, J. Med. Food 21 (2018) 30–38.

[3]K. Toda, S. Takeda, S. Hitoe, S. Nakamura, H. Matsuda, H. Shimoda, J. Nat. Med. 70 (2016) 163–172.

[4]H. Kobayashi, E. Horiguchi-Babamoto, M. Suzuki, H. Makihara, H. Tomozawa, M. Tsubata, T. Shimada, K. Sugiyama, M. Aburada, J. Nat. Med. 70 (2016) 54–61.

[5]J. Wattanathorn, S. Muchimapura, T. Tong-Un, N. Saenghong, W. Thukhum-Mee, B. Sripanidkulchai, Evid. Based. Complement. Alternat. Med. 2012 (2012) 732816.

[6]K. Promthep, W. Eungpinichpong, B. Sripanidkulchai, U. Chatchawan, Med. Sci. Monit. Basic Res. 21 (2015) 100–108.

[7]T. Shimada, T. Horikawa, Y. Ikeya, H. Matsuo, K. Kinoshita, T. Taguchi, K. Ichinose, K. Takahashi, M. Aburada, Fitoterapia 82 (2011) 1272–1278.

[8]S. Yoshino, M. Kim, R. Awa, H. Kuwahara, Y. Kano, T. Kawada, Food Sci Nutr 2 (2014) 634–637.

[9]M. Matsushita, T. Yoneshiro, S. Aita, T. Kamiya, N. Kusaba, K. Yamaguchi, K. Takagaki, T. Kameya, H. Sugie, M. Saito, J. Nutr. Sci. Vitaminol. 61 (2015) 79–83.

[10]A. Nakata, Y. Koike, H. Matsui, T. Shimadad, M. Aburada, J. Yang, Nat. Prod. Commun. 9 (2014) 1291–1294.

[11]S.K. Wattanapitayakul, M. Suwatronnakorn, L. Chularojmontri, A. Herunsalee, S. Niumsakul, S. Charuchongkolwongse, N. Chansuvanich, J. Ethnopharmacol. 110 (2007) 559–562.

[12]P. Weerateerangkul, S. Palee, K. Chinda, S.C. Chattipakorn, N. Chattipakorn, J. Cardiovasc. Pharmacol. 60 (2012) 299–309.

[13]P. Tep-Areenan, P. Sawasdee, M. Randall, Phytother. Res. 24 (2010) 1520–1525.

[14]P. Tep-areenan, K. Ingkaninan, M.D. Randall, Asian Biomed. 4 (2010) 103–111.

[15]P. Temkitthawon, T.R. Hinds, J.A. Beavo, J. Viyoch, K. Suwanborirux, W. Pongamornkul, P. Sawasdee, K. Ingkaninan, J. Ethnopharmacol. 137 (2011) 1437–1441.

[16]P. Sawasdee, C. Sabphon, D. Sitthiwongwanit, U. Kokpol, Phytother. Res. 23 (2009) 1792–1794.

[17]H.-I. Moon, S.-B. Cho, J.-H. Lee, Y.-C. Lee, J.-H. Lee, C.-H. Lee, S.-K. Kim, Phytother. Res. 25 (2011) 1215–1217.

[18]C. Jansakul, K. Tachanaparuksa, M.J. Mulvany, Y. Sukpondma, Eur. J. Pharmacol. 691 (2012) 235–244.