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Our general recommendation is to take Qualia Skin with food because it contains several different fat-soluble nutrients (e.g., Astaxanthin, Lycopene). Fat-soluble compounds are more bioavailable when consumed with dietary fat, so it’s best when they are consumed with or near the end of a meal or snack that contains some fat. But, if it is much more convenient for you to take Qualia Skin without food, we don’t think the bioavailability advantage should outweigh convenience and would encourage you to take it in the way that would be easiest for you to fit into your schedule.